NCT07126743

Organic Pollutant Build-Up in Body Fat and Stomach Tissue Linked to Obesity Levels

Accumulation Profiles of Specific Organic Pollutants in Adipose and Gastric Tissues of Bariatric Surgery Patients and Their Clinical Correlations With Obesity Severity

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Dong Peng · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study looks at whether certain environmental chemicals, called organic pollutants, build up in the body fat and stomach tissues of people with obesity who are having weight-loss (bariatric) surgery. These pollutants can come from things like plastics, pesticides, or industrial waste, and may affect health in different ways. The investigators will measure the amount of these pollutants in tissue samples taken during surgery and see if the levels are different in people with mild, moderate, or severe obesity. By understanding these patterns, the investigators hope to learn more about how environmental factors may influence obesity and related health problems. The findings could help guide future prevention and treatment strategies for patients.

Detailed description

Obesity is a complex health condition influenced by both lifestyle and environmental factors. Among these factors, persistent organic pollutants (POPs) - such as certain plastic-related chemicals, pesticides, and industrial byproducts - have raised growing concern due to their ability to accumulate in human tissues over time and potentially interfere with metabolism. This study focuses on patients with obesity who are undergoing bariatric surgery. During surgery, the investigators will collect small samples of adipose (fat) tissue and gastric tissue under sterile conditions. These samples will be analyzed for the presence and concentration of specific organic pollutants using validated laboratory methods. The investigators will compare pollutant accumulation patterns across patients with varying levels of obesity severity, aiming to identify possible associations between pollutant burden and obesity-related clinical characteristics. The results are expected to provide new insights into the environmental contributions to obesity, beyond diet and physical activity. By clarifying how pollutant accumulation in different tissues relates to obesity severity, the findings could help inform prevention strategies, refine clinical management, and highlight the need for targeted public health policies addressing environmental exposures.

Conditions

• Obesity &Amp; Overweight

Interventions

Type	Name	Description
OTHER	exposure to organic pollutant	Small samples of subcutaneous and visceral adipose tissue will be analyzed for the presence and concentration of specific organic pollutants using validated analytical chemistry methods, such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS).

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-08-17
• Last updated: 2025-08-17

Locations

1 site across 1 country: China