NCT07126717

Acute Effects of Zynamite® S in Cognitive Function and Mood

Confirmatory Study on the Acute Effects of Zynamite® S on Cognitive Function and Mood in University Students: a Randomized, Double-blind, Placebo-controlled Crossover Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Nektium Pharma SL · Industry
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The present study sought to confirm the cognitive and mood benefits of a standardized soluble mango leaf extract, named as Zynamite® S. A placebo or a single dose of the botanical extract (100 mg) was administered and its acute effects on mental function and mood were evaluated before product intake, at 30 min, 3 h, and 5 h post-ingestion.

Detailed description

The present study is a double-blind, randomized, placebo-controlled crossover clinical trial that aimed to evaluate the effects of a standardized soluble mango leaf extract (Zynamite® S) on cognitive performance and mood. The study included 88 healthy university students aged 18-25 years. Participants received a single 100 mg dose of Zynamite® S or a placebo. Cognitive performance was evaluated by using the Trail Making Test (TMT) to assess executive functions, the Digit Symbol Substitution Test (DSST) for processing speed, and the Stroop Color and Word Test and the Stroop Interference Test to evaluate selective attention and cognitive flexibility. Additionally, mood was assessed using the Spanish short version of the Profile of Mood States (POMS). All the assessments were conducted before product intake, at 30 min, 3 h, and 5 h post-ingestion.

Conditions

• Cognitive Performance
• Mood

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Food-grade maltodextrin
DIETARY_SUPPLEMENT	Zynamite® S	Water-soluble mango leaf extract standardized to 60% of mangiferin

Timeline

• Start date: 2025-05-12
• Primary completion: 2025-06-02
• Completion: 2025-06-09
• First posted: 2025-08-17
• Last updated: 2025-08-17

Locations

1 site across 1 country: Spain