NCT07125937

Silver Diamine Flouride in Arresting Enamel Caries

ROLE OF SILVER DIAMINE FLUORIDE (SDF) IN ARRESTING ENAMEL CARIES IN ADULTS REPORTING TO DENTAL COLLEGE HITEC-IMS TAXILA

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (actual)
• Sponsor: HITEC-Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This interventional study aims to evaluate the effectiveness of 38% Silver Diamine Fluoride (SDF) in arresting enamel caries in adults aged 18-50 years. Dental caries is a biofilm-mediated, multifactorial disease that can cause progressive tooth damage. Conventional treatments are invasive and costly, whereas SDF offers a non-invasive, low-cost alternative. A total of 250 patients meeting the inclusion criteria will be treated with SDF following the UCSF protocol. Lesions will be evaluated clinically using ICDAS and radiographically using ICCMS at 3 weeks and 3 months post-intervention. The primary outcome is the proportion of enamel caries lesions arrested after treatment. Data will be analyzed using the chi-square test.

Conditions

• Carious Lesion

Interventions

Type	Name	Description
DRUG	38% Silver Diamine Fluoride	A topical ammonia solution containing silver and fluoride ions applied directly to enamel caries lesions. Application will follow the UCSF protocol: lesions will be cleaned, isolated, and treated with SDF for 2 minutes using a microbrush applicator.

Timeline

• Start date: 2024-05-07
• Primary completion: 2025-05-07
• Completion: 2025-05-07
• First posted: 2025-08-15
• Last updated: 2025-08-15

Locations

1 site across 1 country: Pakistan