NCT07124130

Lactated Ringer's and Dextrose 5% vs Only Lactated Ringer's in Labor

Parenteral Lactated Ringer's Plus Dextrose 5% vs Lactated Ringer's in Labor: A Randomized Control Trial on Maternal and Neonatal Outcomes

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 158 (estimated)
• Sponsor: Eastern Virginia Medical School · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to determine which of two types of standard intravenous (IV) fluids (a combination of 5% dextrose and Lactated Ringers solution and Lactated Ringers solution alone) has a better influence on labor when inducing labor in pregnant women. The main questions it aims to answer are: 1. Does the use of 5% dextrose and Lactated Ringers lead to a shorter labor than the use of just Lactated Ringers? 2. Does the use of 5% dextrose and Lactated Ringers increase the risk of neonatal hypoglycemia when compared to Lactated Ringers? Participants in this trial will be randomly assigned to one of two groups: a group that receives a solution of 5% dextrose and Lactated Ringers, and a group that receives Lactated Ringers alone. Researchers will compare the outcomes of the two groups to see which IV fluid is more effective.

Conditions

• Induced Labor

Interventions

Type	Name	Description
DRUG	5% Dextrose (D5) in Normal Saline (NS)	A solution of 5% dextrose and lactate ringer will be given to one group of participants.
DRUG	Lactate Ringer	A Lactate Ringer solution will be given to one group of participants.

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2025-08-15
• Last updated: 2025-08-22

Locations

2 sites across 2 countries: United States, Italy

Regulatory

• FDA-regulated drug study