NCT07122765

Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis

Effect of Caloric Content And Timing of Meal On Postprandial Substrate Oxidation And Pulse Wave Analysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: George Washington University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The overarching aim of this research is to study the effects of caloric content and timing of meals on measures of postprandial metabolism and cardiovascular response 1. Determine the effect of caloric content on measures of postprandial metabolic flexibility and pulse wave analysis to a mixed meal challenge. 2. Determine the effect of meal timing on measures of postprandial metabolic flexibility and pulse wave analysis to a mixed meal challenge. Hypothesis: 1) that hypercaloric meals will result in significantly reduced indices of metabolic flexibility and pulse wave analysis as compared to eucaloric meals and 2) eucaloric meals consumed later in the day will result in significantly reduced metabolic flexibility and pulse wave analysis as compared to eucaloric meals consumed in the morning.

Conditions

• Feeding
• Metabolism
• Indirect Calorimetry
• Blood Flow Velocity
• Pulse Wave Analysis
• Pulse Wave Velocity
• Carbohydrate Metabolism
• Fatty Acid Metabolism
• Healthy Participants

Interventions

Type	Name	Description
OTHER	Mixed Meal Feeding Challenge	Liquid flavored Ensure Plus Shake of varying caloric content based on individual daily estimated caloric need

Timeline

• Start date: 2024-11-03
• Primary completion: 2026-01-15
• Completion: 2026-01-15
• First posted: 2025-08-14
• Last updated: 2026-02-25

Locations

1 site across 1 country: United States