NCT07122128

EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)

Saliva as Early Detection Tool for Oral Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Liaquat University of Medical & Health Sciences · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.

Detailed description

The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.

Conditions

• The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	saliva a a diagnostic tool for early detection of oral cancer	Three groups will be compared on the basis of cytology, genes and biochemical analysis

Timeline

• Start date: 2021-06-01
• Primary completion: 2025-12-30
• Completion: 2026-06-30
• First posted: 2025-08-14
• Last updated: 2025-08-14

Locations

1 site across 1 country: Pakistan