Trials / Completed
CompletedNCT07121959
A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)
An Open-Label, Phase 1 Study to Characterize the Effects of Belzutifan on the Pharmacokinetics of a MATE1/2K Substrate, Metformin, in Healthy Adult Participants
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 14 (actual)
- Sponsor
- Merck Sharp & Dohme LLC · Industry
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
The goal of this study is to learn how belzutifan (MK-6482) affects the levels of metformin in a healthy person's body over time. Researchers will study levels of metformin in the blood and urine in healthy volunteers after taking metformin alone (Period 1) and metformin with belzutifan (Period 2).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metformin | Oral Tablet |
| DRUG | Belzutifan | Oral Tablet |
Timeline
- Start date
- 2025-08-18
- Primary completion
- 2025-09-13
- Completion
- 2025-09-26
- First posted
- 2025-08-14
- Last updated
- 2025-10-15
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT07121959. Inclusion in this directory is not an endorsement.