NCT07121348

Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 9 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration

Detailed description

The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)

Conditions

• Necrotic Immature Permanent Incisors

Interventions

Type	Name	Description
PROCEDURE	Platelet rich fibrin	platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration

Timeline

• Start date: 2025-07-28
• Primary completion: 2026-07-28
• Completion: 2026-12-01
• First posted: 2025-08-13
• Last updated: 2025-08-13

Locations

1 site across 1 country: Egypt