NCT07121127

Effect of Fu's Subcutaneous Needling for Age-related Macular Degeneration

• Status: Not Yet Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 38 (estimated)
• Sponsor: Zhiming Yan · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This pilot randomized controlled trial aims to evaluate the efficacy and safety of FSN in improving symptoms in patients with dAMD.38 eligible participants will be recruited and randomly assign them in a 1:1 ratio to the FSN group and the control group. Throughout the study, both groups will take oral vitamin C and vitamin E supplements for a total of 28 days. Participants in the FSN group will receive four treatment sessions over two weeks. Both groups will be assessed at the end of the FSN treating period during the mid-study period, with ocular blood flow dynamics measured using OCTA, followed by a two-week follow-up. The primary outcome of this trial is the change in visual acuity from baseline to week 2, with secondary outcomes including visual field, visual function scale, macular thickness, central avascular zone area vascular density, and choroidal thickness.

Conditions

• Age - Related Macular Degeneration (AMD)

Interventions

Type	Name	Description
COMBINATION_PRODUCT	FSN+Vitamin supplement	Fu's subcutaneous needling with oral Vitamin C and vitamin E supplements
DRUG	Vitamin Supplements	oral Vitamin C and vitamin E supplements

Timeline

• Start date: 2026-07-07
• Primary completion: 2029-08-08
• Completion: 2030-03-09
• First posted: 2025-08-13
• Last updated: 2025-08-13