NCT07120581

Hyperbaric Oxygen Therapy Used on Severely Injured Healthy Individuals With Fungal Infections

Hyperbaric Oxygen Therapy as Salvage Therapy for Healthy, Severely Injured, Mechanically Ventilated Invasive Fungal Infection Cases Resistant to Therapy

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 7 (actual)
• Sponsor: Assaf-Harofeh Medical Center · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about the effects of Hyperbaric Oxygen Therapy on healthy individual who suffer from invasive fungal infection caused by severe trauma, who do not respond to conventional treatment. The main question it aims to answer is: Does the treatment aid in eradicating the infection and improve the overall outcome of such patients?

Conditions

• Invasive Fungal Infections
• Hyperbaric Oxygen Therapy

Interventions

Type	Name	Description
OTHER	Hyperbaric Oxygen Therapy	Hyperbaric Oxygen Therapy at increasing pressure to 2.8 ATA for 2 hours sessions. Breaks of 5 every 20 minutes from the oxygen to air to avoid hyperoxia. Continued for the duration of the hospitalization in the ICU on a daily basis.

Timeline

• Start date: 2024-08-04
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2025-08-13
• Last updated: 2025-08-13

Locations

1 site across 1 country: Israel