NCT07119060

Ablative Technique For Ovarian Preservation In Endometrioma

Monocentric, Controlled, Randomized Trial: Comparison of Pregnancy Rates in Women With One or More Endometriomas, Treated by Cystectomy, Plasma Vaporization, or Sclerotherapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 332 (estimated)
• Sponsor: Clinique Tivoli Ducos · Academic / Other
• Sex: Female
• Age: 18 Years – 43 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare pregnancy rates after different surgical treatments for endometriomas in adult women who have one or more ovarian cysts (endometriomas) larger than 2 cm requiring surgery. The main questions it aims to answer are: How many women become pregnant within 24 months after surgery ? What are the birth rates and different types of pregnancies (natural, with fertility treatments, and those continuing beyond 12 weeks)? How often do the endometriomas come back after surgery? What surgery-related complications occur? How do pain levels change after treatment? Researchers will compare different surgical treatment groups to see if one approach results in better pregnancy outcomes and fewer complications. Participants will: Be randomly assigned to different surgical treatment groups Undergo surgery for their endometriomas and endometriosis Attend follow-up visits at 3 months and 24 months after the procedure Have their pregnancy outcomes, pain levels, and potential complications monitored throughout the study period

Conditions

• Endometrioma
• Fertility

Interventions

Type	Name	Description
PROCEDURE	Cystectomy	Surgical removal of the endometrioma by gently pulling the cyst wall away from the ovarian tissue (divergent traction technique)
PROCEDURE	plasma vaporization	It consists of destroying the cyst wall (vaporization) using plasma energy
PROCEDURE	Sclerotherapy	Ethanol sclerotherapy destroys the endometriotic tissue lining the inner wall of the cyst through prolonged contact with 96% alcohol

Timeline

• Start date: 2025-09-18
• Primary completion: 2034-07-01
• Completion: 2035-01-01
• First posted: 2025-08-12
• Last updated: 2026-03-19

Locations

1 site across 1 country: France