NCT07117084

Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes

Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes (IMPACT-PCI) Study: A Multicenter Cohort Study Based on Coronary CT Angiography

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Despite the widespread use of stents, previous studies have shown that stent implantation mainly relieves symptoms but may not significantly improve long-term outcomes in patients with stable coronary artery disease. Identifying the types of plaques that are most likely to benefit from stenting is essential for improving personalized treatment. This study explores whether coronary computed tomography angiography (CCTA)-derived imaging biomarkers of coronary plaques are associated with increased risk of adverse outcomes after percutaneous coronary intervention (PCI). Around 2,000 patients who underwent CCTA followed by stent placement were included. Advanced software was used to quantify plaque inflammation and composition. Findings from this research may help guide personalized treatment strategies in patients undergoing PCI.

Conditions

• Coronary Artery Disease
• Percutaneous Coronary Intervention (PCI)
• Atherosclerosis of Coronary Artery

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CCTA-derived Plaque Quantification	Quantitative analysis of coronary plaque features based on coronary CT angiography using semi-automated software.

Timeline

• Start date: 2021-01-01
• Primary completion: 2024-12-31
• Completion: 2025-12-01
• First posted: 2025-08-12
• Last updated: 2025-08-12

Locations

3 sites across 1 country: China