NCT07115849

Effect of Different Sex Hormone Profiles for the Response to Physical Training

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.

Detailed description

The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.

Conditions

• Eumenorrhea
• Intrauterine Devices, Medicated
• Hormonal Contraception

Interventions

Type	Name	Description
BEHAVIORAL	Physical training	Aerobic and resistance training three times per week. Two supervised training sessions.

Timeline

• Start date: 2025-08-05
• Primary completion: 2026-12-01
• Completion: 2028-12-01
• First posted: 2025-08-11
• Last updated: 2026-03-02

Locations

1 site across 1 country: Denmark