NCT07115719

Withholding and/or Withdrawing Life-sustaining Treatment on Emergency Department Patients' Short- and Long-term Outcomes

Early Decision Effect of Withholding and/or Withdrawing Life-sustaining Treatment on Emergency Department Patients' Short- and Long-term Outcomes: a Retrospective Analysis.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 354 (actual)
• Sponsor: Beaujon Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Background In France, a significant proportion of end-of-life (EOL) decisions occur in emergency departments (EDs), where time constraints and limited resources may hinder optimal care. Although withholding or withdrawing life-sustaining treatments (WHWD) is common in this context, the impact of timing on patient outcomes remains unclear. Objective: To assess how the timing of WHWD decisions influences short- and long-term outcomes among ED patients. Methods: We conducted a retrospective, observational study at Beaujon Hospital's ED (Paris, France) between January 2020 and December 2021. We included 354 adult patients admitted to the observation unit with a WHWD decision. Patients were categorized into early (eWHWD) and late (lWHWD) groups based on the median time to decision. The primary endpoint was 28-day all-cause mortality. Cox regression was used for survival analysis, adjusting for age, sex, comorbidities, functional status, and severity of illness.

Conditions

• WITHOLDING WITHDRAWING in End of Life Situation

Interventions

Type	Name	Description
OTHER	No Intervention: Observational Cohort	NO INTERVENTION

Timeline

• Start date: 2020-01-01
• Primary completion: 2023-04-30
• Completion: 2023-04-30
• First posted: 2025-08-11
• Last updated: 2025-08-11

Locations

1 site across 1 country: France