NCT07114653

The Role of POLE Mutation in High Risk Endometrial Cancer.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Far Eastern Memorial Hospital · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is: What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?

Detailed description

All high-risk recurrent endometrial cancer cases who were treated in a tertiary referral center will be analyzed and subjected to POLE mutation analysis. In addition, survival analysis will be used to analyze the role of POLE mutations in women with high-risk endometrial cancer. We can answers the following. 1. What is the prevalence of POLE mutations in women with high-risk endometrial cancer? 2. What is the role of POLE mutations in real world high-risk endometrial cancer?

Conditions

• Endometrial Neoplasms

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-08-11
• Last updated: 2025-08-11

Locations

1 site across 1 country: Taiwan