NCT07113054

A Clinical Trial to Evaluate the Effect of Grapefruit Juice on the PK/PD of Edoxaban

A Clinical Trial to Evaluate the Effect of Grapefruit Juice on the Pharmacokinetics and Pharmacodynamics of Edoxaban in Healthy Adults

• Status: Active Not Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Hyewon Chung · Academic / Other
• Sex: All
• Age: 19 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to evaluate the effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of edoxaban in healthy adults

Detailed description

Pharmacokinetics and pharmacodynamics of edoxaban without coadministration of grapefruit juice will be compared with those after administration of grapefruit juice.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Edoxaban 60 MG [Lixiana]	Single administration of edoxaban
OTHER	Edoxaban 60 MG [Lixiana] + Grapefruit Juice	Coadministration of edoxaban and grapefruit juice

Timeline

• Start date: 2025-09-02
• Primary completion: 2025-09-24
• Completion: 2025-10-01
• First posted: 2025-08-08
• Last updated: 2025-09-16

Locations

1 site across 1 country: South Korea