NCT07112768

LH/FSH, Testosterone, Prolactin, and Ferritin in PCOS Patients in Jordan

The Role of LH/FSH, Testosterone, Prolactin, and Ferritin in PCOS Patients in Jordan

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 140 (actual)
• Sponsor: Future University in Egypt · Academic / Other
• Sex: Female
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder impacting women of reproductive age. Characterized by chronic anovulation, hyperandrogenism, and the presence of multiple small ovarian cysts. Despite its widespread occurrence, a comprehensive study particularly within the Jordanian population remains limited. Aim of the study: The study aimed to assess the serum levels of the Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, Testosterone, Prolactin, and Ferritin in Jordanian women diagnosed with PCOS

Detailed description

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder impacting women of reproductive age. Characterized by chronic anovulation, hyperandrogenism, and the presence of multiple small ovarian cysts. Despite its widespread occurrence, a comprehensive study particularly within the Jordanian population remains limited. Aim of the study: The study aimed to assess the serum levels of the Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, Testosterone, Prolactin, and Ferritin in Jordanian women diagnosed with PCOS. Materials and Methods: A total 80 women aged between 20-41 years with confirmed PCOS diagnosis and 60 age matched healthy control were enrolled. Participant completed a structured questionnaire and provided informed consent .Blood samples were collected for measurement of LH, FSH, LH/FSH ratio, testosterone, prolactin, and ferritin levels using standardized laboratory protocol. Results: There were significant differences between the PCOS and control groups in the levels of LH, FSH, LH/FSH ratio, total testosterone, prolactin, and ferritin (p\<0.05 for all). Specifically, the PCOS group showed higher levels of LH, testosterone, prolactin, and ferritin, while FSH levels were significantly lower. Additionally, positive correlations were observed between LH and testosterone, FSH and prolactin, and between ferritin and both LH and the LH/FSH ratio. Conclusions: The altered hormonal and biochemical profiles observed in PCOS patients emphasize the role of these biomarkers in diagnosing and understanding the pathophysiology of PCOS. These findings could support better clinical management and inform future research, particularly in the Jordanian patients.

Conditions

• PCOS (Polycystic Ovary Syndrome)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum levels of LH, FSH, testosterone, prolactin, and ferritin	Measurement of both hormonal and biochemical markers in Jordanian PCOs females, including Serum levels of LH, FSH, testosterone, prolactin, and ferritin)

Timeline

• Start date: 2024-01-02
• Primary completion: 2024-04-10
• Completion: 2024-04-22
• First posted: 2025-08-08
• Last updated: 2025-08-08

Locations

1 site across 1 country: Jordan