NCT07111039

Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventila

Pilot Study to Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventilation (CMV) During Anesthesia for Robotic-Assisted Gynecological and Genitourinary Operative Procedures

• Status: Suspended
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: H. Lee Moffitt Cancer Center and Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a pilot study to determine if pulmonary function (lung compliance and ventilation/perfusion matching) is improved using APRV during general anesthesia, compared to the standard CMV. APRV will be tested during anesthesia in 12 patients undergoing robotic-assisted gynecological or genitourinary surgical procedures for definitive cancer treatment, who will also receive CMV.

Conditions

• Gynecologic Cancer
• Genitourinary Cancer

Interventions

Type	Name	Description
OTHER	Airway Pressure Release Ventilation	APRV
OTHER	Conventional Mechanical Ventilation	CMV

Timeline

• Start date: 2026-03-01
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2025-08-08
• Last updated: 2026-02-02

Locations

1 site across 1 country: United States