NCT07110896

Study Evaluating the Effect of Humiome® Post LB on Stress, Anxiety, and Cognition in Aging Adults

A Randomized, Placebo-controlled, Double-blind Clinical Study to Evaluate the Effect of Humiome® Post LB on Stress, Anxiety, and Cognition in Aging Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 236 (estimated)
• Sponsor: dsm-firmenich Switzerland AG · Industry
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

To assess the effect of 3 months of daily consumption of a postbiotic (inactivated lactic acid bacteria) Humiome® Post LB on stress measured by the Depression Anxiety Stress Scale-21 (DASS-21) adjusted on baseline in study participants when compared to placebo

Detailed description

A double-blinded, randomised and placebo-controlled study will be conducted to assess the effect of 3 months of daily consumption of a postbiotic (inactivated lactic acid bacteria), Humiome® Post LB, on stress measured by the Depression Anxiety Stress Scale-21 (DASS-21) adjusted for baseline in study participants when compared to placebo. The study will be in healthy subjects who are getting older (ageing population) and will measure factors such as stress, sleep, anxiety as well as gut microbiome. The intervention period will be 90 days, and study will include 236 subjects in two arms (active and placebo),

Conditions

• Healthy Aging

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Humiome Post LB (Postbiotic)	Heat-inactivated lactobacilli with fermented medium (a postbiotic) in 340mg powder format
DIETARY_SUPPLEMENT	Placebo	Microcrystalline cellulose, 340mg powder format

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-10-01
• Completion: 2026-11-01
• First posted: 2025-08-08
• Last updated: 2026-03-11

Locations

3 sites across 2 countries: France, Germany