NCT07109713

The Effect Cranberry-Based Products on the Female Microbiome

A Randomized, Parallel, Controlled Trial Investigating the Effects a Cranberry-Based Products on the Female Microbiome

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Ocean Spray Cranberries, Inc. · Industry
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The overall objective of this clinical trial is to compare the effects of a cranberry-based product to a placebo-control product on vaginal and GI microbiome outcomes and associated participant reported outcomes in generally healthy pre-menopausal women

Detailed description

Among various strategies explored to modulate the composition and function of different microbiomes, dietary interventions, like the consumption of cranberry-based products have garnered interest due to their historical use and emerging scientific evidence suggesting beneficial effects on host health. Cranberries are rich in bioactive compounds, notably polyphenols such as proanthocyanidins, which have been investigated for their potential to influence microbial adhesion and growth, especially in the genitourinary tract. While cranberry phenolic compounds generally exhibit poor bioavailability, they have been shown to be metabolized by gut microbiota through fermentation in the distal intestine, yielding bioavailable and bioactive bacteria-derived metabolites. These findings highlight the critical need to understand the potential crosstalk between human microbiome ecosystems and how dietary cranberries might modulate this interaction to impact health outcomes.

Conditions

• Vaginal Microbiome
• Gut Microbiome
• Gut Health

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Active	Cranberry Beverage
DIETARY_SUPPLEMENT	Placebo	Placebo Beverage

Timeline

• Start date: 2025-08-05
• Primary completion: 2025-12-19
• Completion: 2025-12-20
• First posted: 2025-08-07
• Last updated: 2025-08-14

Locations

1 site across 1 country: United States