NCT07108465

Comparative Experimental Study Between Bupivacaine and Ropivacaine Regarding Efficacy in Third Molar Removal Surgery Under General Anesthesia

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Henrique Tedesco · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare the efficacy of bupivacaine and ropivacaine in third molar removal surgery under general anesthesia in healthy volunteers. The main question aims to determine whether there is any difference in vital signs, hemostasis and postoperative pain between ropivacaine and bupivacaine in patients undergoing third molars extraction under general anesthesia. Researchers will compare bupivacaine and ropivacaine in a split-mouth study to determine if one drug is more effective in third molar extraction surgery under general anesthesia (better hemostasis, less postoperative pain, and fewer changes in vital signs). Participants will undergo a single surgical procedure and complete the Visual Analog Scale to record postoperative pain

Conditions

• Third Molars Extraction

Interventions

Type	Name	Description
DRUG	Bupivacaine 0,5%	Injection of bupivacaine 0,5% in group A
DRUG	Ropivacaine 0,75%	Injection of ropivacaine 0,75% in group B

Timeline

• Start date: 2025-07-01
• Primary completion: 2025-09-30
• Completion: 2025-12-31
• First posted: 2025-08-07
• Last updated: 2026-01-05

Locations

1 site across 1 country: Brazil