NCT07108296

A Study on Cardiopulmonary Exercise Tolerance Standards for Healthy Chinese Population

Multi-center Clinical Cohort Study on Cardiopulmonary Exercise Tolerance Standards in Chinese Healthy Population

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 4,620 (estimated)
• Sponsor: Affiliated Hospital of Changchun University of Chinese Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim to achieve automated, standardized, and uniform collection, analysis, and AI modeling of large-scale cardiopulmonary exercise testing (CPET) data. The ultimate goals are: To establish reference standards for cardiopulmonary exercise capacity in the Chinese healthy population. To develop machine learning-based predictive models for key CPET variables (e.g., peak VO₂) tailored to Chinese demographics. To compare performance differences between domestically produced and imported CPET devices.

Conditions

• Oxygen Consumption
• Cardiorespiratory Fitness

Interventions

Type	Name	Description
OTHER	cardiopulmonary exercise testing (CPET)	In this study, the cardiopulmonary exercise testing (CPET) system used breath-by-breath continuous analysis for gas exchange and ventilation variables. The protocol included spirometry with an 8-breath data collection method. The cycle ergometer workload ranged from 10 to 40 W/min using a RAMP protocol. The standard CPET protocol comprised a 3-min rest, 3-min warm-up, 8 - 12 min incremental exercise phase, and 3-min each of active and passive recovery.

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-12-30
• Completion: 2027-03-30
• First posted: 2025-08-07
• Last updated: 2025-08-11

Locations

15 sites across 1 country: China