NCT07106333

Assessment of Ozone Therapy for Management of Post-Extraction Localized Alveolar Osteitis

Management of Post-Extraction Localized Alveolar Osteitis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Menoufia University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This clinical study investigates the effectiveness of ozone therapy in comparison to conventional treatment for alveolar osteitis (AO), a common painful complication following tooth extraction. Forty patients diagnosed with dry socket will be randomly divided into two groups. Group A will receive traditional treatment with normal saline irrigation and analgesics, while Group B will be treated using ozonated water, ozonated gel, and analgesics. Both groups will be monitored over a two-week period to evaluate pain levels, healing progression, and other clinical indicators. The study aims to assess the palliative and regenerative benefits of ozone therapy in managing AO, potentially offering an alternative to conventional symptomatic treatments.

Detailed description

Alveolar osteitis (AO), commonly referred to as "dry socket," is a frequent postoperative complication following tooth extraction. It typically presents 1-3 days post-extraction with severe pain due to premature loss or breakdown of the blood clot within the extraction socket. While the exact pathogenesis remains controversial, enhanced fibrinolytic activity, bone trauma, and bacterial contamination are considered primary contributing factors. The incidence is notably higher in mandibular third molars. Traditional management approaches-such as saline irrigation, antibiotics, and eugenol-based dressings-are often palliative and do not directly target the underlying cause. Ozone therapy, with its antimicrobial, analgesic, and wound-healing properties, has recently emerged as a potential alternative. Ozone, when applied in water or gel forms, is believed to promote clot stability, reduce pain, and enhance soft tissue regeneration. Aim of the Study: To assess and compare the palliative (pain-relieving) and regenerative (healing-promoting) effects of ozone therapy versus conventional treatment in patients suffering from alveolar osteitis.

Conditions

• Alveolar Osteitis

Interventions

Type	Name	Description
OTHER	Topical Ozone Therapy	The intervention involves local application of ozone in two forms: Ozonated Water - used for irrigation of the extraction socket. Ozonated Gel - applied topically inside the socket to promote healing and reduce pain. Both are used after socket debridement and bleeding provocation, followed by standard analgesic administration (Diclofenac potassium).
OTHER	Irrigation with saline	The intervention involves irrigation with saline

Timeline

• Start date: 2025-08-01
• Primary completion: 2025-12-01
• Completion: 2026-02-01
• First posted: 2025-08-06
• Last updated: 2025-08-06