NCT07105618

Total Intravenous Anesthesia in Patients Undergoing Craniotomy

Comparison of Dexmedetomidine Versus Fentanyl or Magnesium Sulphate as Adjuncts to Propofol-Based Total Intravenous Anesthesia in Patients Undergoing Craniotomy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (estimated)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.

Detailed description

Total intravenous anesthesia, particularly with propofol-based regimens, has gained favor in neurosurgical procedures for its neuroprotective properties, and reduced intracranial pressure; however, the choice of adjunct agents in total intravenous anesthesia remains a subject of ongoing investigation, especially regarding their influence on hemodynamic stability, analgesia, brain relaxation, and postoperative outcomes. Total intravenous anesthesia techniques for craniotomy allow rapid recovery and stable hemodynamic parameters, so they decrease the hospital stay. The current study will compare the efficacy and safety profiles of dexmedetomidine, fentanyl, and magnesium sulfate as adjuncts in total intravenous anesthesia for patients undergoing craniotomy.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine as an adjunct to total intravenous anesthesia.
DRUG	Fentanyl	Fentanyl as an adjunct to total intravenous anesthesia.
DRUG	Magnesium	Magnesium sulphate as an adjunct to total intravenous anesthesia.

Timeline

• Start date: 2025-08-10
• Primary completion: 2026-05-01
• Completion: 2026-06-01
• First posted: 2025-08-06
• Last updated: 2025-11-21

Locations

1 site across 1 country: Egypt