NCT07105085

Long-Term Outcomes of ABO-Incompatible Versus Compatible Living Donor Liver Transplantation

Long-Term Outcomes of ABO-Incompatible Versus Compatible Living Donor Liver Transplantation: A Single-Center Retrospective Study

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 511 (actual)
• Sponsor: Seoung Hoon Kim · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This retrospective cohort study investigates the long-term outcomes of ABO-incompatible (ABO-I) versus ABO-compatible (ABO-C) living donor liver transplantation (LDLT). A total of 511 patients at a single high-volume transplant center in Korea. The study aims to compare overall survival and the incidence of biliary complications.

Detailed description

This retrospective cohort study investigates the long-term outcomes of ABO-incompatible (ABO-I) versus ABO-compatible (ABO-C) living donor liver transplantation (LDLT). A total of 511 patients underwent LDLT between January 2012 and December 2022 at a single high-volume transplant center in Korea. Among them, 121 received ABO-I grafts using a rituximab-based desensitization protocol, while 390 underwent ABO-C LDLT. The study aims to compare overall survival and the incidence of biliary complications, as well as to identify risk factors specific to each group. This analysis provides insights into the long-term safety and efficacy of ABO-I LDLT in regions with low deceased donor organ availability.

Conditions

• Liver Transplantation
• Liver Diseases

Interventions

Type	Name	Description
PROCEDURE	living donor liver transplantation	other intervention cannot be applied.

Timeline

• Start date: 2012-01-01
• Primary completion: 2022-12-31
• Completion: 2025-07-01
• First posted: 2025-08-05
• Last updated: 2025-08-05