NCT07103876

Parathyroidectomy and Mobility Study

Rescuing Mobility Function Through Surgical Removal of the Parathyroid Gland

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 60 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates whether surgical removal of the parathyroid gland (parathyroidectomy) improves physical function and mobility in older adults with primary hyperparathyroidism (PHPT). PHPT, a common endocrine disorder in older adults, is associated with reduced muscle strength, mobility, and quality of life. This prospective observational study will enroll up to 80 participants aged 60 and older undergoing parathyroidectomy at UF Health. Participants will complete physical performance tests, wear an Actigraph device to assess physical activity, and provide blood samples for biomarker analysis at pre- and post-operative time points. The goal is to characterize changes in physical function and activity following surgery and to identify biomarkers that may predict mobility improvements. Findings will help inform future larger-scale studies and could expand surgical indications for PHPT in older adults.

Conditions

• Hyperparathyroidism
• Parathyroid
• Mobility

Timeline

• Start date: 2025-08-15
• Primary completion: 2026-11-01
• Completion: 2027-03-31
• First posted: 2025-08-05
• Last updated: 2025-09-29

Locations

1 site across 1 country: United States