NCT07099131

Effective Interventions to Overcome Severe Gag Reflex

• Status: Not Yet Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Tufts University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the use of various techniques in alleviating gag reflex following gag reflex stimulation. Primary aim: To compare if there is any reduction in gag reflex from each of the following interventions * Acupuncture (CV-24) * Tape * Anesthetic spray Secondary aim: to compare the degree of gag reduction

Detailed description

The purpose of this study is to evaluate the use of various techniques in alleviating gag reflex following gag reflex stimulation. Primary aim: To compare if there is any reduction in gag reflex from each of the following interventions * Acupuncture (CV-24) * Tape * Anesthetic spray Secondary aim: to compare the degree of gag reduction

Conditions

• Gagging

Interventions

Type	Name	Description
DRUG	Anesthetic spray	will be applied to back of the throat for 10 seconds; their chin will also be concealed from the GSI examiner using a small cup and masking tape.
DEVICE	Acupuncture	A 6C file (endodontic instrumentation file) will be placed on the patient's mentolabial fold (CV24). This file will be concealed by a small paper cup; A clean alcohol wipe will be used to clean the mentolabial area prior to placing the "acupuncture needle" (6 C-File).
GENETIC	Masking Tape	A piece of commercially available masking tape will be adhered to the patient's mentolabial fold and concealed by the small paper cup

Timeline

• Start date: 2025-12-07
• Primary completion: 2027-12-07
• Completion: 2028-12-07
• First posted: 2025-08-01
• Last updated: 2025-08-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study
• FDA-regulated device study