NCT07098234

Effect of Vitamin-D as an Adjuvant to Phototherapy in Reduction of Indirect Serum Bilirubin

Determination of the Effect of Vitamin-D as an Adjuvant to Phototherapy in Reduction of Indirect Serum Bilirubin Among Neonates With Exaggerated Physiological Hyperbilirubinemia.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Muhammad Aamir Latif · Academic / Other
• Sex: All
• Age: 3 Days – 8 Days
• Healthy volunteers: Not accepted

Summary

The study aimed at filling the gaps by evaluating the effectiveness of vitamin-D as an adjuvant to phototherapy in reduction of indirect serum bilirubin among neonates with exaggerated physiological hyperbilirubinemia.

Detailed description

If vitamin-D has been found effective as an adjuvant to phototherapy in the treatment of exaggerated physiological hyperbilirubinemia, it may help to reduce the serum bilirubin level rapidly. It may also reduce the complications by shortening the duration of phototherapy to offer better patient compliance and better patient outcomes.

Conditions

• Hyperbilirubinemia

Interventions

Type	Name	Description
DRUG	Vitamin D3	Neonates were given vitamin D3 (cholecalciferol) in an oral drops formulation (400 IU/drop), at a dose of 400 IU once a day until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours as an adjuvant therapy to phototherapy.
PROCEDURE	Phototherapy	Neonates received only phototherapy until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours.

Timeline

• Start date: 2022-07-01
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2025-08-01
• Last updated: 2025-08-08

Locations

1 site across 1 country: Pakistan