NCT07097038

Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy

Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy: a Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Henan Provincial People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Traditional opioid analgesia is a method to treat moderate to severe pain. However, the use of opioids is not without risks. When treating acute pain, patients may have hypotension, respiratory depression, hypoxia, nausea and vomiting, irritability and pruritus. The aim of this study was to evaluate the analgesic effect and safety of g-protein-biased μ - opioid receptor agonists Oliceridine and oxycodone in vitrectomy.

Detailed description

a total of 120 patients scheduled for vitrectomy were randomly divided into Oliceridine group (n = 60) and oxycodone group (n = 60). The main outcome measure was visual analogue scale (VAS) at 2 hours after operation, and the secondary outcome measures included intraoperative analgesic drug addition, VAS scores at 6 and 24 hours after operation, respiratory depression (oxygen saturation \< 90%) and incidence of adverse reactions (nausea, vomiting, dizziness).

Conditions

• Vitrectomy

Interventions

Type	Name	Description
DRUG	Oliceridine	Intraoperative analgesia should be administered with Oliceridine
DRUG	Oxycodone	Oxycodone is used for intraoperative analgesia

Timeline

• Start date: 2025-07-01
• Primary completion: 2025-12-01
• Completion: 2026-07-01
• First posted: 2025-07-31
• Last updated: 2025-07-31