NCT07096908

Tirzepatide Use in People With Obesity and Type 1 Diabetes

Treatment With Tirzepatide of the Disease of Obesity in People With Type 1 Diabetes

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Dasman Diabetes Institute · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

Tirzepatide, a gut hormone-based medication, has shown promising results in treating obesity, with \~22% weight loss and mild side effects. However, patients with type 2 diabetes typically experience only about 15% weight loss with tirzepatide, despite tolerating the medication well. Its effects in people with both obesity and type 1 diabetes remain largely unknown. Although tirzepatide is not approved for glycemic control in type 1 diabetes, it is licensed for obesity treatment in Gulf and Europe. In Kuwait, more than a quarter of people with type 1 diabetes also have obesity, presenting a unique opportunity to study tirzepatide's impact. This randomized, double-blind controlled trial will evaluate the safety and efficacy of tirzepatide in patients with type 1 diabetes and obesity, comparing usual care with the maximum tolerable dose of tirzepatide to assess its impact on weight loss. The findings may help address important safety concerns and have the potential to inform and influence future clinical practice.

Conditions

• Type1diabetes
• Obesity

Interventions

Type	Name	Description
DRUG	Tirzepatide	weekly injections
DRUG	Placebo	weekly injections

Timeline

• Start date: 2025-07-31
• Primary completion: 2028-02-25
• Completion: 2028-08-01
• First posted: 2025-07-31
• Last updated: 2025-08-03

Locations

1 site across 1 country: Kuwait

Regulatory

• FDA-regulated drug study