NCT07095179

Effects of Inspiratory Muscle Exercise on Health

Acute Effects of Intermittent Inspiratory Muscle Training on Blood Glucose and Vascular Function Responses

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: National Taiwan Normal University · Academic / Other
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether inspiratory muscle training has an immediate effect on energy expenditure, heart rate, blood glucose, blood pressure, and arterial stiffness in healthy adults, obese adults, and adults with type 2 diabetes.

Detailed description

Participants will be asked to complete two trials involving intermittent exercise, which will include eupnea and inspiratory muscle training (IMT), as well as a resting control condition, in a randomized crossover study design. The trials will be separated by a minimum of 48 hours and will be completed within a 7-day period. Throughout all trials, participants will be required to remain relaxed and seated on an adjustable examination bed. For the IMT intensity, participants will utilize an inspiratory muscle training device (PowerBreathe Plus, Powerbreathe International Ltd., UK) and adjust the resistance to a level at which breathing continuously for 20 breaths is perceived as "somewhat hard" (RPE = 13), according to the Rating of Perceived Exertion (RPE) scale. This will take place during a 3.5-hour oral glucose tolerance test (OGTT). During the trials, participants may watch television or read; however, typing on a laptop or computer will be prohibited.

Conditions

• Intermittent Inspiratory Muscle Training
• Eupnea

Interventions

Type	Name	Description
BEHAVIORAL	Eupnea	Participants will breathe normally.
BEHAVIORAL	Intermittent inspiratory muscle training (IIMT)	Intermittent inspiratory muscle training (IIMT) will be conducted throughout the trial

Timeline

• Start date: 2026-03-01
• Primary completion: 2027-08-01
• Completion: 2027-08-01
• First posted: 2025-07-31
• Last updated: 2026-02-06