NCT07093463

Colon-delivered Riboflavin and Gut Microbiota Composition

The Benefit of Colon-delivered Riboflavin (Riboflavin-cd) vs. Conventional Riboflavin on Gut Microbiota Composition and Metabolic Output in Healthy Aging Subjects - a Pilot Proof of Concept Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: dsm-firmenich Switzerland AG · Industry
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Recent studies suggest B-vitamins such as riboflavin to possess prebiotic-like effects. However, there is still a lack of understanding of the exact host health benefits vs. conventional systemically available vitamin forms. The present study explores the benefit of colon-delivered vitamin B2 vs. conventional vitamin B2 in comparison to placebo in an aging population on gut microbiota and metabolic activity as well as gut health.

Conditions

• Microbiome Dysbiosis
• Gut Health

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Colon-delivered riboflavin	10 mg of colon-delivered riboflavin
DIETARY_SUPPLEMENT	Conventional riboflavin	10 mg of conventional riboflavin
OTHER	Microcrystalline Cellulose	10 mg microcrystalline cellulose

Timeline

• Start date: 2025-07-18
• Primary completion: 2026-08-01
• Completion: 2026-09-01
• First posted: 2025-07-30
• Last updated: 2026-03-19

Locations

1 site across 1 country: Germany