NCT07093424

Relationship Between Complex Regional Pain Syndrome and Magnesium Depletion Score

The Relationship of Magnesium Depletion Score With the Development of Complex Regional Pain Syndrome in Patients With Traumatic Extremity Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 117 (actual)
• Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Complex Regional Pain Syndrome (CRPS) is a condition triggered by trauma such as surgery or a fracture. It is characterised by pain and limited mobility that are disproportionate to the severity of the trauma and the clinical course. Magnesium is recognised for its anti-inflammatory and antioxidant properties. The magnesium depletion score (MDS) is a more reliable and comprehensive scoring tool than measuring serum and urine magnesium levels. This score takes into account the patient's use of diuretics and proton pump inhibitors, their alcohol consumption, and their glomerular filtration rate. Impaired magnesium distribution may be a risk factor for CRPS development due to increased nociceptor activity. This study aimed to investigate whether an increased MDS score is a risk factor for CRPS development in individuals with traumatic limb injury.

Conditions

• Complex Regional Pain Syndrome (CRPS)

Interventions

Type	Name	Description
OTHER	scoring	magnesium depletion score calculation

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-01-01
• Completion: 2025-06-01
• First posted: 2025-07-30
• Last updated: 2025-07-30

Locations

1 site across 1 country: Turkey (Türkiye)