NCT07092683

Mediation Analysis in Cardiac Surgery

Mediating Role of Intraoperative Red Blood Cell Transfusion in the Relationship Between Preoperative Anaemia and Postoperative Complications in Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13,683 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.

Conditions

• Anemia
• Cardiac Surgery
• Transfusion
• Mediation

Interventions

Type	Name	Description
OTHER	anemia	preoperative anemia
OTHER	nonanemia	preoperative nonanemia

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-05-01
• Completion: 2025-05-01
• First posted: 2025-07-30
• Last updated: 2026-01-05

Locations

1 site across 1 country: China