NCT07091656

Contrast-enhanced Computed Tomography and Acute Kidney Injury

Incidence and Risk Factors of Contrast-associated Acute Kidney Injury in Patients Hospitalised After Contrast-enhanced Computed Tomography in the Emergency Department

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,463 (actual)
• Sponsor: Beaujon Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: —

Summary

Rationale and objectives: Since 1930 it has been accepted that intravenous injection of io-dinated contrast agent as part of contrast-enhanced computed tomography (CE-CT) imaging can induce a contrast-associated acute kidney injury (CA-AKI). For the last 10 years, studies have investigated this iatrogenia. However, those works didn't concern French population and particularly patient hospitalised after emergency department (ED) visit. This study as-sessed the CA-AKI incidence and factor risks in patients hospitalised after a CE-CT in ED. This was a retrospective cohort observational study in the ED of the Beaujon University Hospital between October 31st 2019 to January 24th 2022. Patients over 16 years old who presented to the emergency department and underwent an intravenous contrast-enhanced CT were eligible. To be included, patients were required to have at least two creatinine measurements: one taken within 24 hours before CT and a second measurement taken between 48 hours to the seventh day following the initial test. The CT examination had to be performed at Beaujon Hospital with the injection of iodinated contrast agents such as IOMERON® (iomeprol) or XENETIX® (iobitridol).

Conditions

• Contrast-associated Acute Kidney Injury

Interventions

Type	Name	Description
OTHER	there is no intervention	NO INTERVENTION

Timeline

• Start date: 2019-10-31
• Primary completion: 2022-01-24
• Completion: 2022-12-31
• First posted: 2025-07-29
• Last updated: 2025-07-29

Locations

1 site across 1 country: France