NCT07090577

Multiomics Profiling of CSF in Cardiac Arrest Survivors

Serial Multiomics Profiling Using Serum and Cerebrospinal Fluid Samples Following Out-of-hospital Cardiac Arrest: a Prospective Observational Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Chungnam National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is: A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury? Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

Conditions

• Cardiac Arrest (CA)
• Hypoxic-Ischemic Brain Injury
• Post-Resuscitation Syndrome

Timeline

• Start date: 2025-07-22
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-07-29
• Last updated: 2025-07-29

Locations

1 site across 1 country: South Korea