NCT07087873

Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 128 (estimated)
• Sponsor: Xuanwu Hospital, Beijing · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations. It also evaluates the effectiveness of transcranial electrical stimulation in alleviating clinical symptoms of IIDDs patients, and analyzes the key factors affecting the treatment efficacy. By uncovering the overall and individual characteristics of IIDDs, this study seeks to enhance therapeutic outcomes through personalized neuromodulation programs. The findings will provide a basis for applying non-invasive brain stimulation (NIBS) in IIDDs treatment and offer new ideas for future personalized medicine approaches.

Conditions

• Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
• MS (Multiple Sclerosis)
• NMOSD
• Acute Disseminated Encephalomyelitis
• Transcranial Alternating Current Stimulation

Interventions

Type	Name	Description
DEVICE	Neuroelectrical modulation group	Participants received transcranial electrical stimulation using the Spanish Neuroelectrics StarStim 32 device.
DEVICE	Pseudo-neuromodulation group	Pseudo-stimulation is performed using the same equipment and procedures as in the neuromodulation group.

Timeline

• Start date: 2025-05-30
• Primary completion: 2027-10-31
• Completion: 2027-10-31
• First posted: 2025-07-28
• Last updated: 2025-07-28

Locations

1 site across 1 country: China