NCT07087210

In Vivo Quantitative Mapping of Mitochondrial Cardiac Membrane Potential in Heart Failure

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Matthieu Pelletier-Galarneau, MD MSc · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

This research aims to develop a new method to measure how well mitochondria are working using a special imaging technique called PET (positron emission tomography) with a tracer called 18F-TPP+. This tracer helps us visualize and measure mitochondrial function in a non-invasive way.

Detailed description

Our study has three main goals: 1. Measure Mitochondrial Function in Different Groups: The investigators will compare mitochondrial function in three groups: healthy active individuals, sedentary individuals, and heart failure patients. The investigators expect to see higher mitochondrial function in active individuals and lower function in heart failure patients. The investigators will also test the consistency of our measurements. 2. Correlate Mitochondrial Function with Health Indicators: The investigators will see if our mitochondrial function measurements relate to other health markers, such as exercise capacity, heart health, muscle strength, and cognitive function. 3. Improve the Production of the Tracer: The investigators will refine how they make the 18F-TPP+ tracer to make it more efficient and cost-effective for widespread use in research and clinical settings.

Conditions

• Mitochondrial Function

Interventions

Type	Name	Description
OTHER	Positron Emission Tomography (PET)	18F-TPP+ PET/CT imaging

Timeline

• Start date: 2024-11-25
• Primary completion: 2028-09-01
• Completion: 2028-09-01
• First posted: 2025-07-25
• Last updated: 2025-07-25

Locations

1 site across 1 country: Canada