NCT07086937

Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children

To Compare the Efficacy of Nitrazoxinide Based Triple Therapy Versus Standard Triple Therapy for Eradication of Helicobacter Pylori Infection in Children at a Tertiary Care Hospital

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Muhammad Aamir Latif · Academic / Other
• Sex: All
• Age: 2 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

This study aimed at comparing the efficacy of nitazoxanide-based triple therapy versus standard triple therapy for eradication of Helicobacter pylori infection in children at a tertiary care hospital.

Detailed description

The findings could guide clinical practice and influence guidelines, improving the management of H. pylori infections in the pediatric population. Not much local data also exists comparing the effectiveness of adding nitazoxanide to the standard triple therapy in children with H. pylori infection. If nitazoxanide-based therapy proves superior, it could reduce the incidence of antibiotic resistance associated with standard triple therapy.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Nitazoxanide	Children were given nitazoxanide, PPI, and clarithromycin for 14 days.
DRUG	Metronidazole	Children received MTZ, PPI, and clarithromycin for 14 days.
DRUG	PPI	Children were given omeprazole for 14 days.
DRUG	Clarithromycin	Children were given clarithromycin for 14 days.

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2025-07-25
• Last updated: 2025-07-25

Locations

1 site across 1 country: Pakistan