NCT07085975

The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 33 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough. However, the safety, feasibility, and repeatability of this procedure is not widely known. In this study, we will perform ATP cough challenges in healthy individuals and in patients with mild asthma and chronic cough to better understand the safety, feasibility, and repeatability of these challenges. Such information will guide the future conduct of ATP cough challenges to measure cough hypersensitivity and identify patients who may better respond to ATP-blocking therapies.

Conditions

• Chronic Cough (CC)
• Asthma

Interventions

Type	Name	Description
DRUG	Adenosine 5'-triphosphate	Participants will inhale increasing doubling concentrations of adenosine 5'-triphosphate dissolved in 0.9% saline through the Aerogen Solo vibrating mesh nebulizer.

Timeline

• Start date: 2025-08-05
• Primary completion: 2026-08-01
• Completion: 2026-10-01
• First posted: 2025-07-25
• Last updated: 2025-08-29

Locations

1 site across 1 country: Canada