NCT07085754

Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Yuhui Qiu · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.

Detailed description

This is a randomized controlled trial designed to enroll 60 healthy volunteers. Stratified randomization will be used, with three strata defined by APOE genotype (APOE ε3/3, APOE ε4 carriers, and APOE ε2 carriers) in a 1:1:1 ratio. Within each stratum, participants will be randomly assigned in a 1:1 ratio to either the acute sleep-deprivation group or the non-acute sleep-deprivation group. The intervention will consist of 24 hours of acute sleep deprivation. The primary outcome measure is the change from baseline in plasma Aβ42 on the first day after randomization.

Conditions

• Sleep
• Sleep Deprivation

Interventions

Type	Name	Description
BEHAVIORAL	Sleep Deprivation	Sleep deprivation for up to 24 hours with no naps or other sleep periods

Timeline

• Start date: 2025-08-08
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2025-07-25
• Last updated: 2025-12-24

Locations

1 site across 1 country: China