NCT07084285

Cervical Facet Injection of Corticosteroids for the Management of Cervicobrachialgia

Cervical Facet Injection of Corticosteroids for the Management of Cervicobrachialgia : Protocol for a Randomized Pilot Study

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective is to evaluate the efficacy of a single posterior intra-articular injection of dexamethasone on radicular pain (RP) at 1 month in the treatment of uncomplicated chronic cervicobrachial neuralgia (CBN) in adults, resistant to well-conducted first-line medical treatment.

Detailed description

Cervicobrachial Neuralgia (CBN) is a common condition caused by the compression of a nerve root (C5, C6, C7, or C8) in the cervical spine. In 10% of cases, the duration of symptoms exceeds 3 months, at which point it is considered chronic. Two main etiologies are distinguished : * Soft disc herniation, * uncodiscarthrotic foraminal stenosis. The pathophysiology involves both mechanical compression and local inflammation. The initial management is typically medical, provided if there are no signs of severity. If medical treatment fails or if signs of severity are present, surgical intervention is required. The role of corticosteroid injections in the therapeutic strategy in France remains controversial. Literature on the efficacy of cervical spinal injections is heterogeneous and limited, the safety of such injections is debated, and product availability is restricted. We hypothesize that posterior intra-articular dexamethasone injection would be effective for radicular pain resistant to first-line medical treatment.

Conditions

• Cervicobrachial Neuralgia

Interventions

Type	Name	Description
DRUG	Dexamethasone	A single 4mg (1mL) dexamethasone injection via the posterior intra-articular route, under CT guidance
OTHER	Isotonic saline solution	1 mL isotonic saline solution, injectable, for a single posterior intra-articular injection, under CT guidance.

Timeline

• Start date: 2026-01-01
• Primary completion: 2028-02-01
• Completion: 2028-05-01
• First posted: 2025-07-24
• Last updated: 2025-08-12

Locations

1 site across 1 country: France