NCT07084116

Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin

Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin: an Open-label Within-subject Randomized Study

• Status: Enrolling By Invitation
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to determine whether once nightly application of tretinoin 0.1% cream to forearm skin reduces the frequency of skin tears and bruising (solar purpura), and changes skin thickness over a period of 6 months.

Detailed description

Easy bruising and tearing of forearm skin is common with aging and can cause activity restriction, infection, and pain. Chronic exposure to UV light from the sun causes skin thinning and loss of supportive collagen over time. Thin skin tears easily and blood vessels normally protected by collagen rupture, causing bruises. Tretinoin is a prescription vitamin A cream that has been shown to increase skin thickness and collagen. Tretinoin is FDA approved for treatment of acne. We are trying to figure out if putting tretinoin cream on the forearms of adults with thin skin prevents skin tears and bruising. This research study is looking for 30 people with a history of skin tears in the United States. The VA Palo Alto expects to enroll 30 research study subjects.

Conditions

• Skin Tear
• Solar Purpura
• Dermatoporosis

Interventions

Type	Name	Description
DRUG	Tretinoin 0.1% cream	Tretinoin 0.1% cream formulation.
DRUG	Bland cream (non-drug)	Bland cream formulation.

Timeline

• Start date: 2025-07-14
• Primary completion: 2026-01-01
• Completion: 2026-02-01
• First posted: 2025-07-24
• Last updated: 2025-07-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study