NCT07082244

Implant Phenotype Modification Via GBR and ADM

Phenotype Modification Via Guided Bone Regeneration and Acellular Dermal Matrix Simultaneous to Delayed Implant Placement: A Double Arm Randomized Controlled Clinical Trial.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for improving the health, appearance, and stability of the bone and gums surrounding the implant.

Detailed description

The study will treat patients that need a single implant at a previously edentulous site (\>3 months post extraction) that requires phenotypic modification. These patients will receive an implant with simultaneous GBR, with half of the participants also receiving an ADM graft.

Conditions

• Horizontal Ridge Deficiency

Interventions

Type	Name	Description
PROCEDURE	Dental implant placement	Participants will have a dental implant placed at a toothless site
PROCEDURE	Guided bone regeneration with collagen membrane	Participants will receive guided bone regeneration at a toothless site with bone substitute and a collagen membrane.
PROCEDURE	Guided bone regeneration with acellular dermal matrix.	Participants will receive guided bone regeneration at a toothless site with bone substitute and an acellular dermal matrix.

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-07-01
• Completion: 2026-09-01
• First posted: 2025-07-24
• Last updated: 2025-08-21

Locations

1 site across 1 country: United States