NCT07082088

Abutment Hydrophilicity on Soft Tissue Morphogenesis

Effect of Abutment Hydrophilicity on Soft Tissue Morphogenesis: Histological CCT

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Paolo Pesce · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy. The main questions it aims to answer are: Does argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments? Does the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness? Researchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis. Participants will: Undergo implant placement with immediate connection of either a treated or untreated healing abutment. Have plaque and bleeding indices recorded at 3 months. Undergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).

Conditions

• Missing Tooth/Teeth

Interventions

Type	Name	Description
DEVICE	the test group were placed in an Argon plasma reactor	the test group were placed in an Argon plasma reactor

Timeline

• Start date: 2025-07-31
• Primary completion: 2025-10-30
• Completion: 2025-10-30
• First posted: 2025-07-24
• Last updated: 2025-07-24