NCT07081581

Analgesic Effect of Serratus Plane Block With Adjuvant Agents in Breast Cancer Surgery

Comparison of the Postoperative Analgesic Efficacy of Serratus Plane Block With Different Adjuvant Agents in Breast Cancer Surgery

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Pain after breast surgery has been described as moderate to severe in intensity and, if inadequately treated, increases postoperative morbidity, hospital cost, and the incidence of persistent postoperative pain. Serratus anterior plane block is an interfascial injection technique for analgesia of the chest wall. The aim of this study was to investigate the effect of magnesium and dexmedetomidine as adjuvant agents on postoperative analgesia in serratus anterior plane block in patients undergoing modified radical mastectomy.

Detailed description

In this prospective, double-blind, randomised controlled study, a total of 75 patients aged 30-70 years, who were planned for elective modified radical mastectomy after ethics committee approval, were included. Patients were randomly divided into three groups. After induction of general anaesthesia, serratus anterior plane block was applied to all patients. Group B received bupivacaine 30 ml (0.25%), Group D received bupivacaine 30 ml (0.25%) + dexmedetomidine 1μg/kg, Group M received bupivacaine 30 ml (0.25%) + 500 mg magnesium sulphate. Haemodynamic parameters, numerical rating scale (NRS) scores, number of tramadol use with patient-controlled analgesia device, additional analgesic drug consumption and side effects were recorded at 2, 6, 12 and 24 hours postoperatively.

Conditions

• Breast Cancer
• Post Operative Pain

Interventions

Type	Name	Description
DRUG	Bupivacain	In Group B( control group), bupivacaine was given as additional medication in the serratus block application.
DRUG	Bupivacaine and Magnesium sulfate	In Group M, bupivacaine and magnesium were given as additional medication in the serratus block application.
DRUG	Bupivacaine and Dexmedetomidine ile Blokaj	In Group D, bupivacaine and dexmedetomidine were given as additional medication in the serratus block application.

Timeline

• Start date: 2022-08-01
• Primary completion: 2023-02-01
• Completion: 2023-03-01
• First posted: 2025-07-23
• Last updated: 2025-07-23

Locations

1 site across 1 country: Turkey (Türkiye)