NCT07080866

Brain Health Oneida

Brain Health and Root Causes of Stroke Risk Disparity in Wisconsin Native Americans

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 19 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 55 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this observational study is to better understand the relationship between stroke risk factors and brain MRI measures in the Native American population. Participants will undergo: * Carotid ultrasound * Magnetic resonance imaging (MRI) * Cognitive testing

Detailed description

Researchers' central hypothesis is that Native Americans (NAs) suffer from chronic psychological stress (PS) and inter-generational trauma related to historical loss (HL) which are manifested as inflammatory proteomic changes, leading to atherosclerotic vessel wall injury, stroke and vascular cognitive impairment (VCI). The researchers present a study to determine if MRI brain health metrics such as structural and functional connections, cerebral blood flow measures, brain morphometry are correlated with cardiovascular risk factors, atherosclerotic disease burden, blood inflammatory proteins, and scores on the Oneida cultural nutritional programs.

Conditions

• Oneida Nation Members

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI	Participants will undergo a 60-minute MRI
DIAGNOSTIC_TEST	Carotid ultrasound	Participants will undergo an ultrasound

Timeline

• Start date: 2025-09-02
• Primary completion: 2026-02-23
• Completion: 2026-02-23
• First posted: 2025-07-23
• Last updated: 2026-02-27

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated device study