NCT07079852

The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function

• Status: Not Yet Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Manoj Doss · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study will test the effects of psilocybin on memory and cognition in healthy participants using computerized tasks and magnetic resonance imaging (MRI).

Detailed description

In a double-blind, placebo-controlled, repeated measures design in healthy participants, this study will test the effects of psilocybin on memory and cognition in healthy individuals using computerized tasks and magnetic resonance imaging (MRI). A better understanding of the basic neurocognitive effects of psilocybin may allow for minimizing potential harms and maximizing potential benefits of psilocybin therapy.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Placebo	This is an inactive control condition.
DRUG	Psilocybin 15mg	This is a moderate psychoactive dose.

Timeline

• Start date: 2025-09-01
• Primary completion: 2027-08-01
• Completion: 2027-08-01
• First posted: 2025-07-23
• Last updated: 2025-07-23

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study