Trials / Completed
CompletedNCT07079514
Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients
Role of Magnesium Sulphate Versus Placebo on Hemodynamic Changes During Pneumoperitoneum During Laparoscopic Procedures
- Status
- Completed
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Ziauddin University · Academic / Other
- Sex
- All
- Age
- 18 Years – 85 Years
- Healthy volunteers
- Accepted
Summary
The goal of this triple blinded randomized control trial is to compare the effect of magnesium sulphate on the hemodynamic response during pneumoperitoneum creation, along with its impact on postoperative pain, opioid consumption, and post operative nausea vomiting (PONV) in ASA I to III patients undergoing laparoscopic cholecystectomy The main question\[s\] it aims to answer is whether the agent Magnesium Sulphate will blunt the increase in the hemodynamic response during peritoneal insufflation, and will it decrease post operative opioids consumption and prevent nausea vomiting in patients undergoing laparoscopic surgeries. 30 were given placebo and 30 were introduced with magnesium sulphate (3mg) 5 mins before insufflation. The hemodynamic such as, mean arterial pressure (MAP,) systolic (SBP) and diastolic blood pressures (DBP), heart rate (HR) were recorded pre operatively and intraoperatively with intervals of 5mins. Pain score was recorded by VAS scaling and post operative nausea vomiting (PONV) with Yes and No in post operative anesthesia unit (PACU) period.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Placebo | normal saline in 100ml piggy bag |
| DRUG | Magnesium | Magnesium Sulphate will be given as doses of 20-50mg/kg in 2 -3 minutes. In order to standardize the dose in every patient we will be using 3g |
Timeline
- Start date
- 2025-01-06
- Primary completion
- 2025-04-21
- Completion
- 2025-04-21
- First posted
- 2025-07-23
- Last updated
- 2025-07-23
Locations
1 site across 1 country: Pakistan
Source: ClinicalTrials.gov record NCT07079514. Inclusion in this directory is not an endorsement.