NCT07077980

Discovery of HPV T Cell Epitopes and Development of Multi-epitope Vaccines

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Anhui Provincial Hospital · Other Government
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Based on the trend that the incidence and mortality of cervical carcinoma among female cancers worldwide are increasing year by year, the investigators aim to develop a multi-epitope therapeutic vaccine capable of simultaneously activating humoral and cellular immune responses, which is achieved by fusing multiple T-cell epitope immunostimulatory proteins. To obtain information on functional T-cell epitopes to be included in the vaccine, the investigators conducted research starting from clinical cases. By collecting peripheral blood and cancerous tissues from clinical patients, the investigators isolated reactive T-cells and screened for information on T-cell epitopes of HPV antigens.

Conditions

• Cervical Cancer

Timeline

• Start date: 2025-09-01
• Primary completion: 2028-07-01
• Completion: 2033-09-01
• First posted: 2025-07-22
• Last updated: 2025-07-22

Locations

1 site across 1 country: China